Jackie Peyton, a strong-willed and brilliant but very flawed emergency room nurse. This season, Jackie comes to realize that both karma and sobriety can be a pain. In addition to finally confronting her addiction, Jackie's street smarts and sardonic wit are tested even further by an ambitious new hospital administrator determined to run a tight ship and keep Jackie in line.

Hannah Lee is a bright teen girl trapped in the dark southern underworld of violence and guns, drugs and vicious biker gangs. Neglected by her angry sister Amber, her only refuge is her troubled Uncle Donny, who is a drug addict. Both live in fear of Uncle Frank Stinson, who runs the illegal family business with an iron fist, aided by his psychotic younger brother Bobby. But when Amber falls in love with family rival Wild Bill, Hannah realizes there...

Harry and his best friend, Tyrone, are impoverished heroin addicts living in Coney Island, NY. Harry's girlfriend, Marion, is a fellow addict trying to distance herself from her wealthy father. Harry's mother, Sara, spends her days watching television and wants to lose weight to go on a game show. She visits a sleazy doctor who prescribes her amphetamines and soon Sara has a drug habit of her own.

Chronicling the hilarious highs and devastating lows of his tumultuous life, this blackly humorous drama follows Patrick from his childhood trauma at the hands of an abusive father and neglectful mother, to the peak of his heroin addiction, and his attempts to stay sober and support his family.